Frederick, Maryland, the seat of Frederick County. It is on the Monocacy River in the north-central part of the state. Frederick is the trade center for a rich dairying and fruit-producing region and has varied light manufacturing industries. Located in the city are Hood College; Fort Detrick, an army installation; and a national center for cancer research.

Francis Scott Key and Barbara Fritchie, both of whom lived in Frederick, are buried in Mount Olivet Cemetery here. Barbara Fritchie Museum is a replica of the original Fritchie house. The home of Roger B. Taney, the fifth chief justice of the United States, houses the Francis Scott Key Museum. Also here is the National Museum of Civil War Medicine.

Frederick was settled in 1733. During the Civil War, it was occupied alternately by Union and Confederate forces. Frederick has the mayor-council form of government.

Population: 52, 767.