Great Smoky Mountains, a range of the Appalachian Mountains. The Great Smokies lie along the Tennessee-North Carolina border, between the Pigeon and Little Tennessee rivers, and are about equally distant from Knoxville (Tennessee) and Asheville (North Carolina). The range includes most of the highest mountains in the eastern United States. The highest point is Clingmans Dome (6,643 feet [2,025 m]). Among 16 other peaks more than 6,000 feet (1,829 m) high are Mounts Guyot, Le Conte, and Chapman.

The Great Smoky Mountains are named for the blue-gray haze characteristic of the region. Heavily wooded mountain slopes are a source of timber. There are small deposits of clay, copper, and gold.