Wyoming Valley, a region in Luzerne County, Pennsylvania, in the northeastern part of the state. It lies along the Susquehanna River in an anthracite area, and is about 20 miles (32 km) long and 3 to 4 miles (4.8 to 6.4 km) wide. The valley's chief city is Wilkes-Barre.

In colonial times, Pennsylvania and Connecticut claimed the valley. In 1762, a group of people from Connecticut founded a settlement near the site of Wilkes-Barre. Forty Fort was built there. In 1769 Pennsylvanians captured the fort, starting the so-called Yankee-Pennamite Wars. Fighting took place at intervals during 1769–72, 1775, and 1784. The conflict was settled by a compromise that gave the territory to Pennsylvania but allowed the Connecticut settlers to remain.